Manufacturer: SP-LaboratoriesSubstance: CabergolinePackage: One pack contains 20 pills

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SP CABERGOLIN (Cabergoline) One pack contains 20 pillsĀ – Oral Steroids from SP-Laboratories.

Cabergoline is an antagonist of prolonged dopamine receptors. Agent acts mainly on D2-dopamine receptors, to a lesser extent – on D1-dopamine, serotonin, alpha2- and alpha1-adrenergic receptors.

Laboratory studies show that the drug has a direct effect on the synthesis of prolactin by lactotrophies in rats, lactotrophies are located in the pituitary. Blood plasma prolactin levels are significantly reduced, especially in reserpinized individuals.

The hypoplactinemic effect of the agent has been scrutinized in two independent, randomized, double studies involving a placebo-controlled and comparative group. The effect of the substance was studied on women suffering from hyperprolactinemia. Test results improved and the normal menstrual cycle recovered in about 77% women who took the drug 2 times in 7 days at a dose of 0.5 mg. In 73% of the subjects, galactorea disappeared.

Pharmacokinetic parameters are directly proportional to the dosage of the drug. Eating has no effect on the processes of assimilation, metabolism and excretion. After penetration into the LCV, the maximum concentration of the substance in the blood plasma was observed after 2-3 hours. At systematic administration of the preparation its equilibrium concentration is several times higher than concentration at single administration.

It is not fully known what bioavailability Cabergolin has, but it is definitely subjected to the effect of “first passage” through liver tissues. The degree of binding of the agent to plasma proteins varies from 40 to 42%, depending on the dose taken. The drug and its metabolites are rapidly and well distributed across tissues and organs, with the highest concentration found in the pituitary.

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